This post will probably cement my reputation as a crank after the one on Rossi. I followed up on claims from some natural health web sites that Sodium Bicarbonate, Baking Soda, NaHCO3 could have a beneficial effect in cancer.
There are no shortage of web sites purportedly by MDs stating there is “no evidence of beneficial effect whatsoever”, etc. etc.
I was therefore surprised when a short search of the medical literature revealed a number of recent studies demonstrating beneficial effects of bicarbonate on tumors. These include:
A study showing tumor reduction and greatly enhanced survival in mice;
However, it remains possible that this effect may be specific for buffers in the bicarbonate/CO2 family through involvement of carbonic anhydrase activity, which is important to pH regulation in tumors ( 46). Notwithstanding these concerns, however, the dramatic effect of bicarbonate therapy on the formation of breast cancer metastases in this model system warrants further investigation.
A simulation study detailing the possible chemical pathways.
In conclusion, our study, using mathematical models informed by realistic parameter values ( 47– 50), finds that p.o. administration of clinically feasible amounts of NaHCO3 may be sufficient to increase the acidic intratumoral and peritumoral pHe in small tumors. Furthermore, the consequent changes in the tumor-host dynamics may inhibit tumor growth and invasion. Our results suggest further experimental exploration of systemic administration of pH buffers as a novel cancer therapy is warranted.